Señalización celular en enfermedades autoinmunes que afectan al riñón como la nefritis lúpica
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Fecha
2021-06
Autores
Hernández Pérez, Andrea Carolina
Guzmán Pedroza, Angie Pamela
Visbal Meza, Katherine Milene
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Ediciones Universidad Simón Bolívar
Facultad de Ciencias de la Salud
Facultad de Ciencias de la Salud
Resumen
La nefritis lúpica (NL) es una enfermedad desconocida, crónica, inflamatoria, autoinmune de gran importancia dentro de las manifestaciones del Lupus Eritematoso Sistémico (LES)(1). Es importante para el profesional de salud reconocer su clasificación, qué factores afectan directa e indirectamente la condición del paciente, qué tratamientos pueden ser considerados como oportunos y en qué tiempos se debe realizar la atención integral a sus complicaciones. Actualmente, se ha buscado realizar mejoras teniendo en cuenta los cuidados y tratamientos en el paciente ya diagnosticado con el fin de disminuir el impacto de la condición y el deterioro sistémico del mismo evitando un mayor compromiso o una mejor adherencia (2)(3). De igual manera se refleja un gran preámbulo de enfermedades relacionadas con nefritis lúpica siendo esta secundaria a su padecimiento de enfermedades de base en los pacientes, por lo cual es de vital importancia reconocer factores de riesgo y todo lo que conlleva a una falla renal. Objetivos: Conocer el impacto del lupus eritematoso sistémico en el sistema nefrourinario a nivel poblacional. Identificar los factores de riesgo que desencadenan la nefritis lúpica. Comparar las distintas formas de tratamiento existentes para el manejo de la nefritis lúpica. Conclusión: La incidencia de afectación renal del lupus eritematoso sistémico es más frecuente con el progreso de la enfermedad (48), quizás la nefropatía lúpica no está asociada a mal pronóstico ya que se ha estimado un sin número de pacientes tanto como adultos y pediátricos con mantenimiento de la función renal a los 5 y 10 años de evolución.
Lupus nephritis (LN) is an unknown, chronic, inflammatory, autoimmune disease of great importance within the manifestations of Systemic Lupus Erythematosus (SLE) (1). It is important for the health professional to recognize their classification, what factors directly and indirectly affect the patient's condition, what treatments can be considered as appropriate and in what times should comprehensive care for their complications be carried out. Currently, improvements have been sought taking into account the care and treatments in the already diagnosed patient in order to reduce the impact of the condition and its systemic deterioration, avoiding greater commitment or better adherence (2) (3). In the same way, a great preamble of diseases related to lupus nephritis is reflected, this being secondary to its suffering from underlying diseases in patients, for which it is vitally important to recognize risk factors and everything that leads to kidney failure. Objectives: To know the impact of systemic lupus erythematosus on the nephro-urinary system at the population level. Identify the risk factors that trigger lupus nephritis. Compare the different forms of existing treatment for the management of lupus nephritis. Conclusion: The incidence of renal involvement of systemic lupus erythematosus is more frequent with the progress of the disease (48), perhaps lupus nephropathy is not associated with a poor prognosis since a number of patients have been estimated both as adults and pediatric with maintenance of renal function at 5 and10 years of evolution.
Lupus nephritis (LN) is an unknown, chronic, inflammatory, autoimmune disease of great importance within the manifestations of Systemic Lupus Erythematosus (SLE) (1). It is important for the health professional to recognize their classification, what factors directly and indirectly affect the patient's condition, what treatments can be considered as appropriate and in what times should comprehensive care for their complications be carried out. Currently, improvements have been sought taking into account the care and treatments in the already diagnosed patient in order to reduce the impact of the condition and its systemic deterioration, avoiding greater commitment or better adherence (2) (3). In the same way, a great preamble of diseases related to lupus nephritis is reflected, this being secondary to its suffering from underlying diseases in patients, for which it is vitally important to recognize risk factors and everything that leads to kidney failure. Objectives: To know the impact of systemic lupus erythematosus on the nephro-urinary system at the population level. Identify the risk factors that trigger lupus nephritis. Compare the different forms of existing treatment for the management of lupus nephritis. Conclusion: The incidence of renal involvement of systemic lupus erythematosus is more frequent with the progress of the disease (48), perhaps lupus nephropathy is not associated with a poor prognosis since a number of patients have been estimated both as adults and pediatric with maintenance of renal function at 5 and10 years of evolution.
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Palabras clave
Nefritis lúpica, Lupus eritematoso sistémico, Señalización celular, Lupus nephritis, Systemic lupus erythematosus, Cell signaling