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dc.contributor.authorNavar, Ann Marie
dc.contributor.authorMatskeplishvili, Simon T.
dc.contributor.authorUrina-Triana, Miguel
dc.contributor.authorArafah, Mohammed
dc.contributor.authorChen, Jaw-Wen
dc.contributor.authorSukonthasarn, Apichard
dc.contributor.authorCorp dit Genti, Valérie
dc.contributor.authorDaclin, Véronique
dc.contributor.authorPeterson, Eric D.
dc.date.accessioned2021-06-09T20:26:11Z
dc.date.available2021-06-09T20:26:11Z
dc.date.issued2021
dc.identifier.issn19328737
dc.identifier.urihttps://hdl.handle.net/20.500.12442/7897
dc.description.abstractBackground: Half the global burden of cardiovascular disease (CVD) is concentrated in the Asia-Pacific (APAC) region. Hypothesis: Suboptimal control of low-density lipoprotein cholesterol (LDL-C) may play a large role in the burden of CVD in APAC and non-Western countries. Methods: The Acute Coronary Syndrome Management (ACOSYM) registry is a multinational, multicenter, prospective observational registry designed to evaluate LDL-C control in patients within 6 months after hospitalization following an acute coronary syndrome (ACS) event across nine countries. Results: Overall, 1581 patients were enrolled, of whom 1567 patients met the eligibility criteria; 80.3% of the eligible patients were men, 46.1% had ST-elevation myocardial infarction, and 39.5% had non-ST-elevation myocardial infarction. Most (1245; 79.5%) patients were discharged on a high-intensity statin. During the followup, only 992 (63.3%) patients had at least one LDL-C measurement; of these, 52.9% had persistently elevated LDL-C (>70 mg/dl). The patients not discharged on a highdose statin were more likely (OR 3.2; 95% CI 2.1–4.8) to have an LDL-C above the 70 mg/dl LDL-C target compared with those who were discharged on a high-dose statin. Conclusion: Our real-world registry found that a third or more of post-ACS patients did not have a repeat LDL-C follow-up measurement. In those with an LDL-C followup measurement, more than half (52.9%) were not achieving a <70 mg/dl LDL-C goal, despite a greater uptake of high-intensity statin therapy than has been observed in recent evidence. This demonstrates the opportunity to improve post-ACS lipid management in global community practice.eng
dc.format.mimetypepdfspa
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceClinical Cardiologyeng
dc.sourceVol.1 N° 8, (2021)
dc.subjectAcute coronary syndromeeng
dc.subjectIipid managementeng
dc.subjectLow-density lipoprotein cholesteroleng
dc.subjectNon- Western countrieseng
dc.subjectStatin therapyeng
dc.titleProspective evaluation of lipid management following acute coronary syndrome in non-Western countrieseng
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dcterms.referencesMurphy SA, Pedersen TR, Gaciong ZA, et al. Effect of the PCSK9 inhibitor evolocumab on total cardiovascular events in patients with cardiovascular disease. JAMA Cardiol. 2019;4(7):613-619. https:// jamanetwork.com/journals/jamacardiology/fullarticle/2733138.eng
dcterms.referencesDanchin N, Almahmeed W, Al-Rasadi K, et al. Achievement of lowdensity lipoprotein cholesterol goals in 18 countries outside Western Europe: the International ChoLesterol management Practice Study (ICLPS). Eur J Prev Cardiol. 2018;25(10):1087-1094. https://doi.org/ 10.1177/2047487318777079.eng
dcterms.referencesWang Y, Yan BP, Tomlinson B, Lee VWY. Is lipid goal one-size-fits-all: a review of evidence for recommended low-density lipoprotein treatment targets in Asian patients. Eur J Prev Cardiol. 2019;26(14):1496- 1506. https://doi.org/10.1177/2047487319843077.eng
dcterms.referencesNakamura M, Ako J, Arai H, et al. Investigation into lipid management in acute coronary syndrome patients from the EXPLORE-J study. J Atheroscler Thromb. 2019;26(6):559-572. https://doi.org/10.5551/jat.45583.eng
dcterms.referencesLi Y-H, Ueng K-C, Jeng J-S, et al. 2017 Taiwan lipid guidelines for high risk patients. J Formos Med Assoc. 2017;116(4):217-248. https:// doi.org/10.1016/j.jfma.2016.11.013.eng
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
datacite.rightshttp://purl.org/coar/access_right/c_abf2eng
oaire.versioninfo:eu-repo/semantics/publishedVersioneng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.identifier.doiDOI: 10.1002/clc.23623
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/clc.23623
dc.type.spaArtículo científicospa


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