DNA damage, salivary cortisol levels, and cognitive parameters in a nursing team
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Fecha
2020
Autores
Bortolotto, Iranez
Scherer de Brum, Ana Paula
Nikolova Guecheva, Temenouga
Milano de Souza, Larissa
Lia de Paula-Ramos, Ana Ligia
Trindade, Cristiano
Rosat Consiglio, Angelica
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Editor
Elsevier
Resumen
In a cross-sectional study of women in a nursing team at a university hospital in southern Brazil, we studied DNA
damage, salivary cortisol levels, and cognition. DNA damage was measured in blood leukocytes with the comet
assay and the micronucleus test. Salivary cortisol levels were determined upon waking, 30 min later, and at
bedtime. Cognition was evaluated according to the Stroop, Digit span and Word span tests. Cortisol levels on
waking up were associated negatively with the number of years the employee worked at the institution and
positively with the DNA damage in comet assay. Cognitive scores were lower when the cortisol levels were low at
awakening and high at bedtime; and were associated positively with educational level. Cortisol status may influence overall health as well as essential work skills, such as attention.
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Palabras clave
Comet assay, Cortisol, Genotoxicity, Micronucleus test, Occupational health