Prediction of Epitopes in the Proteome of Helicobacter pylori
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Fecha
2018-06
Autores
Navarro-Quiroz, Elkin
Navarro-Quiroz, Roberto
España-Puccini, Pierine
Villarreal, José Luis
Díaz Perez, Anderson
Fernandez Ponce, Cecilia
Bilbao, Jorge
Vasquez, Lucy
Mendoza, Dary Luz
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Canadian Center of Science and Education
Resumen
Helicobacter pylori (H. pylori) is classified by the World Health Organization (WHO) as a group I carcinogen and
is one of the most efficient human pathogens with over half of the world's population colonized by this
gram-negative spiral bacterium. H. pylori can cause a chronic infection in the stomach during early childhood that
persists throughout life due to diverse mechanisms of immune response evasion. H. pylori has several factors
strongly associated with increased risk of disease such as toxins, adhesins, and chemoattractants, some of which
are highly polymorphic, phase variable, and have different functions. Conventional treatments involve the use of
antibiotics. However, treatment frequently fails due to the resistance H. pylori has progressively developed to
antibiotics. This creates the need for different treatments made possible by identifying new therapeutic targets in
the pathogen’s genome.
The purpose of this study was an in silico prediction of T- and B- epitopes in H. pylori proteins. Twenty-two
external membrane proteins from H. pylori Strain 26695 (accession number NC_000915) were identified using the
web tool Vaxign (http://www.violinet.org/vaxign/). A total of one-hundred epitopes (60 class I epitopes and 40
class II epitopes) that could be used to develop novel non-antibiotics drugs for an H. pylori infection were
predicted.
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Palabras clave
Helicobacter pylori, Epitopes, Chronic infection in the stomach