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Is “Leptin Resistance” Another Key Resistance to Manage Type 2 Diabetes?
(Bentham Science Publishers, 2020)
Although novel pharmacological options for the treatment of type 2 diabetes mellitus (DM2) have been observed to modulate the functionality of several key organs in glucose homeostasis, successful regulation of insulin resistance (IR), body weight management, and pharmacological treatment of obesity remain notable problems in endocrinology. Leptin may be a pivotal player in this scenario, as an adipokine which centrally regulates appetite and energy balance. In obesity, excessive caloric intake promotes a low-grade inflammatory response, which ...
The A54T polymorphism in the FABP2 gene and its relationship with obesity
(Saber UCV, Universidad Central de Venezuela, 2020)
Introduction: Obesity is a complex, multifactorial,
and mostly preventable disease affecting, along
with overweight, more than a third of today’s world
population. Variations in the nucleotide sequence of
both metabolic and appetite control genes have been
counted among these non-modifiable factors and are
associated with BMI, lipidic profile, and abdominal
circumference alterations. Methods: An analytical,
non-experimental, and transversal research was
done with the purpose to assess the presence of A54T
polymorphism in the FABP gene ...