Mostrando ítems 1-5 de 5
Metabolic Syndrome and Subclinical Hypothyroidism: A Type 2 Diabetes-Dependent Association
Introduction. Subclinical hypothyroidism (ScH) is an endocrine alteration that is related to cardiovascular risk factors, including those categorized as components of the Metabolic Syndrome (MS). However, findings in prior reports regarding an association between these alterations are inconsistent. The purpose of this study was to determine the relationship between both entities in adult subjects from Maracaibo City, Venezuela. Materials and Methods. The Maracaibo City Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study ...
Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease
(The Korean Society of Nephrology, 2019)
Adipose tissue accumulation in specific body compartments has been associated with diabetes, hypertension and dyslipidemia. Perirenal fat (PRF) may lead to have direct lipotoxic effects on renal function and intrarenal hydrostatic pressure. This study was undertaken to explore the association of PRF with cardiovascular risk factors and different stages of chronic kidney disease (CKD). We studied 103 patients with CKD of different stages (1 to 5). PRF was measured by B-mode renal ultrasonography in the distal third between the cortex and the hepatic ...
Is “Leptin Resistance” Another Key Resistance to Manage Type 2 Diabetes?
(Bentham Science Publishers, 2020)
Although novel pharmacological options for the treatment of type 2 diabetes mellitus (DM2) have been observed to modulate the functionality of several key organs in glucose homeostasis, successful regulation of insulin resistance (IR), body weight management, and pharmacological treatment of obesity remain notable problems in endocrinology. Leptin may be a pivotal player in this scenario, as an adipokine which centrally regulates appetite and energy balance. In obesity, excessive caloric intake promotes a low-grade inflammatory response, which ...
Obesidad Infantil: Un problema de pequeños que se está volviendo grande
(Cooperativa servicios y suministros 212518 RS, 2019)
La obesidad es una enfermedad crónica de comportamiento epidemiológico complejo que se origina de la interacción entre factores genéticos y ambientales, entre los que destacan los patrones de alimentación y el consumo calórico diario, así como el grado de actividad física. Según la Organización Mundial para la Salud (OMS), la obesidad se define como una acumulación anormal y excesiva de grasa corporal. Para el diagnóstico de esta condición en niños y adolescentes se utilizan tablas diseñadas por la OMS que definen a un individuo con sobrepeso ...
Microbiota and Diabetes Mellitus: Role of Lipid Mediators
Diabetes Mellitus (DM) is an inflammatory clinical entity with different mechanisms involved in its physiopathology. Among these, the dysfunction of the gut microbiota stands out. Currently, it is understood that lipid products derived from the gut microbiota are capable of interacting with cells from the immune system and have an immunomodulatory effect. In the presence of dysbiosis, the concentration of lipopolysaccharides (LPS) increases, favoring damage to the intestinal barrier. Furthermore, a pro-inflammatory environment prevails, and a ...