We propose an intelligent computational technique for the image segmentation of a type IV brain tumor, identified as multiform glioblastoma (MGB), which is present in multi-layer computed tomography images. This technique consists of 3 stages developed in the three-dimensional domain. They are: pre-processing, segmentation and validation. During the validation stage, the Dice coefficient (Dc) is considered in order to compare the segmentations of the MGB, obtained automatically, with the segmentations of the MGB generated manually, by a ...