Examinando por Autor "Roque, Willy"
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Ítem Fto gene: historic background and its relationship with chronic-degenerative diseases(Sociedad Latinoamericana de Hipertención, 2018-07-15) Torres, Maritza; Bermúdez, Valmore; Ortiz, Rina; Siguencia, Wilson; Prieto, Carem; Añez, Roberto; Martínez, María Sofía; Angarita Dávila, Lissé; Rojas Gómez, Diana Marcela; Salazar, Juan; González Casanova, Jorge Enrique; Sánchez Guette, Lilibeth; Guillén Burgos, Hernán Felipe; Kuzmar, Isaac; Roque, Willy; Rojas, Edward; Rojas, JoselynAlteraciones en el desarrollo de la atención y la organización conductual pueden configurar cuadros clínicos como el trastorno déficit de atención (TDA) que puede estar acompañado o no de hiperactividad (TDAH), este último parece tener una relación directa con otros diagnósticos de tipo endocrino como la obesidad. El objetivo del estudio es analizar la relación que existe entre el TDAH y la obesidad. Es por ello que se realiza una revisión sistemática de estudios científicos revelando relaciones y diferencias entre ambos trastornos desde una mirada fisiológica, cognoscitiva y comportamental. Se concluye que la relación entre el TDAH y la obesidad se da por factores genéticos, por variaciones dopaminérgicas, cambios en patrones de sueño, desajustes emocionales y por alteraciones en la regulación de la conducta; igualmente influyen factores sociales relacionados con el cuidado en el embarazo y la alimentación de las mujeres antes y durante la gestación.Ítem Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease(The Korean Society of Nephrology, 2019) D´Marco, Luis; Salazar, Juan; Cortez, Marie; Salazar, María; Wettel, Marjorie; Lima-Martínez, Marcos; Rojas, Edward; Roque, Willy; Bermúdez, ValmoreAdipose tissue accumulation in specific body compartments has been associated with diabetes, hypertension and dyslipidemia. Perirenal fat (PRF) may lead to have direct lipotoxic effects on renal function and intrarenal hydrostatic pressure. This study was undertaken to explore the association of PRF with cardiovascular risk factors and different stages of chronic kidney disease (CKD). We studied 103 patients with CKD of different stages (1 to 5). PRF was measured by B-mode renal ultrasonography in the distal third between the cortex and the hepatic border and/or spleen. The PRF thickness was greater in CKD patients with impaired fasting glucose than in those with normal glucose levels (1.10 ± 0.40 cm vs. 0.85 ± 0.39 cm, P < 0.01). Patients in CKD stages 4 and 5 (glomerular filtration rate [GFR] < 30 mL/min/1.73 m2) had the highest PRF thickness. Serum triglyceride levels correlated positively with the PRF thickness; the PRF thickness was greater in patients with triglyceride levels ≥ 150 mg/dL (1.09 ± 0.40 cm vs. 0.86 ± 0.36 cm, P < 0.01). In patients with a GFR < 60 mL/min/1.73 m2, uric acid levels correlated positively with the PRF thickness (P < 0.05). In CKD patients, the PRF thickness correlated significantly with metabolic risk factors that could affect kidney function.Ítem Pyoderma gangrenosum in a patient with type 2 diabetes: a case report(Universidad del Zulia, 2020) Toledo-Contreras, Abdón; Bermúdez, Valmore; Toledo, Andrés José; Salazar, Juan; Martínez, María Sofía; Rojas, Edward; Roque, Willy; Pérez, Arturo; Chacín-González, Maricarmen; Rojas, JoselynWe are presenting a case of patient with type 2 diabetes mellitus that was diagnosed with a soft tissue infection in the lower extremity. This was initially treated as cellulitis and antibiotic treatment was initiated. Due to a poor clinical response, the diagnosis of pyoderma gangrenosum was proposed as part of the differential diagnosis. Skin biopsies and pathology confirmed the diagnosis of pyoderma gangrenosum that had a satisfactory response to steroid treatment.