Examinando por Autor "Prieto, Carem"
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Ítem The A54T polymorphism in the FABP2 gene and its relationship with obesity(Saber UCV, Universidad Central de Venezuela, 2020) Torres, Maritza; Prieto, Carem; Ortiz, Rina; Siguencia, Wilson; Durán, Pablo; Pérez, José; Díaz, María P.; Rojas, Milagros; Chacín, Maricarmen; Cano, Clímaco; Bermúdez, ValmoreIntroduction: Obesity is a complex, multifactorial, and mostly preventable disease affecting, along with overweight, more than a third of today’s world population. Variations in the nucleotide sequence of both metabolic and appetite control genes have been counted among these non-modifiable factors and are associated with BMI, lipidic profile, and abdominal circumference alterations. Methods: An analytical, non-experimental, and transversal research was done with the purpose to assess the presence of A54T polymorphism in the FABP gene in a sub-sample from the Maracaibo City Metabolic Syndrome Prevalence Study. Results: 154 individuals eight subjects were carriers of the A54Tpolymorphism, namely, a genotypic frequency of 5.19 %, with a sex distribution of 50 % for women (n=4) and 50 % (n=4) for men. In respect of alleles similarity degree, 75 % (n=6) were homozygous, and 25 % (n=2) were heterozygous. Obesity diagnosis throughout BMI was only present in 12.50 % (n=1) of the A54T carriers. Conversely, 25 % (n=2) of the carriers were overweighed; 50 % (n=4) were presented as normal-weight people; and only 12.50 % (n=1), in one underweighted person. Conclusion: As in many other studies, we do not find an association between Ala54Thr polymorphism and obesity. This result reinforces the fact of the multifactorial character of these diseases and a carrier state of this polymorphism is not necessarily to experience a higher obesity risk, at least, in our environment.Ítem Association between +45T>G adiponectin polymorphism gene and type 2 diabetes mellitus and metabolic syndrome in a Venezuelan population [version 1; peer review: 2 approved, 1 approved with reservations](F1000 Research Ltda, 2019) Sánchez, María Patricia; Prieto, Carem; Mujica, Endrina; Vergara, Kendry; Valencia, Enifer; Villalobos, Eudymar; Medina, Mayerlim; Parra, Michael; D'Addosio, Rosanna; Hoedebecke, Kyle; Rodríguez, Johel E.; Bermudez, ValmoreBackground: Adiponectin (ADIPOQ) is a hormone primarily synthesized by adipocytes and encoded by the ADIPOQ gene, which exerts anti-inflammatory, antiatheratogenic and insulin sensitizing functions. It has been shown that its plasma concentrations are decreased in individuals with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2), which could be due to variations in the gene coding for this protein. The aim of this study was to detect the +45 T>G polymorphism of the ADIPOQ gene in subjects with DM2 and MS in Maracaibo municipality, Zulia state, Venezuela. Methods: A total of 90 subjects who attended the Center for Metabolic Endocrine Research "Dr. Félix Gómez" were enrolled for this study, 46 of which had MS-DM2 and 44 of which were healthy control individuals. Genomic DNA was extracted from blood samples and PCR-restriction fragment length polymorphism analysis was carried out for the promoter region of the ADIPOQ gene. Likewise, the +45 T> G polymorphism was identified and correlated with MS and DM2 in the studied population. Results: The most frequent allele in both groups was the T allele, and the predominant genotype was homozygous T/T (79%). Genotypes with heterozygous T/G and G/G homozygous polymorphism were more frequent in the control group than in the MS-DM2 group. Regarding the individuals with T/G and G/G genotypes, statistically significant lower mean values were found for fasting glucose, total cholesterol, triacylglycerides, abdominal circumference, and for the medians of systolic and diastolic blood pressure. Odds ratio were calculated for the presence or absence of MS and DM2. Conclusions: The results suggested that the presence of the G allele exerts a protective effect on the carrier individuals, thus avoiding the appearance of the aforementioned metabolic alterations.Ítem Fto gene: historic background and its relationship with chronic-degenerative diseases(Sociedad Latinoamericana de Hipertención, 2018-07-15) Torres, Maritza; Bermúdez, Valmore; Ortiz, Rina; Siguencia, Wilson; Prieto, Carem; Añez, Roberto; Martínez, María Sofía; Angarita Dávila, Lissé; Rojas Gómez, Diana Marcela; Salazar, Juan; González Casanova, Jorge Enrique; Sánchez Guette, Lilibeth; Guillén Burgos, Hernán Felipe; Kuzmar, Isaac; Roque, Willy; Rojas, Edward; Rojas, JoselynAlteraciones en el desarrollo de la atención y la organización conductual pueden configurar cuadros clínicos como el trastorno déficit de atención (TDA) que puede estar acompañado o no de hiperactividad (TDAH), este último parece tener una relación directa con otros diagnósticos de tipo endocrino como la obesidad. El objetivo del estudio es analizar la relación que existe entre el TDAH y la obesidad. Es por ello que se realiza una revisión sistemática de estudios científicos revelando relaciones y diferencias entre ambos trastornos desde una mirada fisiológica, cognoscitiva y comportamental. Se concluye que la relación entre el TDAH y la obesidad se da por factores genéticos, por variaciones dopaminérgicas, cambios en patrones de sueño, desajustes emocionales y por alteraciones en la regulación de la conducta; igualmente influyen factores sociales relacionados con el cuidado en el embarazo y la alimentación de las mujeres antes y durante la gestación.