Examinando por Autor "Gonzalez-Torres, Henry"
Mostrando 1 - 3 de 3
Resultados por página
Opciones de ordenación
Ítem Primary prevention for acute kidney injury in ambulatory patients(Taylor & Francis, 2020) Musso, Carlos G.; Rosell, Camila; Gonzalez-Torres, Henry; Ordonez, Juan D.; Aroca-Martinez, GustavoAcute kidney injury (AKI) is a heterogeneous group of conditions characterized by a sudden decrease in glomerular filtration rate (GFR), which usually induces the accumulation of nitrogenous-waste substances in the blood. It is expressed as an increase in serum creatinine levels (≥ 0.3 mg/dl within 48 hours or ≥1.5 times from baseline within the previous 7 days) or by a urine volume reduction of ˂0.5 ml/kg/h in 6 hours [1]. AKI is a relevant condition since it is usually associated with 1–7% and 30–50% of hospital and intensive care unit (ICU) admissions, respectively; showing a significant morbidity-mortality rate, and progression to chronic kidney disease (CKD) [1–7]. Even though many strategies have been proposed to achieve an early AKI diagnosis (e.g. novel biomarkers, informatics alarms), and an AKI effective treatment (e.g. renal protective drugs, biocompatible renal replacement therapies), both objectives remain unachieved; therefore, AKI prevention is currently the best ‘therapeutic’ strategy for this condition.Ítem Profiling analysis of circulating microRNA in peripheral blood of patients with class IV lupus nephritis(Xu-jie Zhou, Peking University First Hospital, CHINA, 2017-11-14) Navarro-Quiroz, Elkin; Pacheco-Lugo, Lisandro; Navarro-Quiroz, Roberto; Lorenzi, Hernan; España-Puccini, Pierine; DõÂaz-Olmos, Yirys; Almendrales, Lisneth; Olave, Valeria; Gonzalez-Torres, Henry; Diaz-Perez, Anderson; Dominguez, Alex; Iglesias, Antonio; García, Raul; Aroca-Martinez, GustavoRenal involvement in Systemic Lupus Erythematous (SLE) patients is one of the leading causes of morbidity and a significant contributor to mortality. It's estimated that nearly 50% of SLE individuals develop kidney disease in the first year of the diagnosis. Class IV lupus nephritis (LN-IV) is the class of lupus nephritis most common in Colombian patients with SLE. Altered miRNAs expression levels have been reported in human autoimmune diseases including lupus. Variations in the expression pattern of peripheral blood circulating miRNAs specific for this class of lupus nephritis could be correlated with the pathophysiological status of this group of individuals. The aim of this study was to evaluate the relative abundance of circulating microRNAs in peripheral blood from Colombian patients with LN-IV. Circulating miRNAs in plasma of patients with diagnosis of LN-IV were compared with individuals without renal involvement (LNN group) and healthy individuals (CTL group). Total RNA was extracted from 10 ml of venous blood and subsequently sequenced using Illumina. The sequences were processed and these were analyzed using miRBase and Ensembl databases. Differential gene expression analysis was carried out with edgeR and functional analysis were done with DIANA-miRPath. Analysis was carried out using as variables of selection fold change ( 2 o -2) and false discovery rate (0.05). We identified 24 circulating microRNAs with differential abundance between LN-IV and CTL groups, fourteen of these microRNAs are described for the first time to lupus nephritis (hsa-miR-589-3p, hsa-miR-1260b, hsa-miR-4511, hsa-miR- 485-5p, hsa-miR-584-5p, hsa-miR-543, hsa-miR-153-3p, hsa-miR-6087, hsa-miR-3942-5p, hsa-miR-7977, hsa-miR-323b-3p, hsa-miR-4732-3p and hsa-miR-6741-3p). These changes in the abundance of miRNAs could be interpreted as alterations in the miRNAs-mRNA regulatory network in the pathogenesis of LN, preceding the clinical onset of the disease. The findings thus contribute to understanding the disease process and are likely to pave the way towards identifying disease biomarkers for early diagnosis of LN.Ítem Reporte de 4 casos COVID-19 hospitalizados en unidad de cuidados intensivos en una institución hospitalaria en Barranquilla, Colombia(Asociación Colombiana de Nefrología e Hipertensión Arterial, 2020) Iglesias Pertuz, Shirley; Aroca-Martinez, Gustavo; Velez-Verbel, María; Cadena Osorio, Andrés; Correa-Monterrosa, Mileidys; Cadena-Bonfanti, Andrés; Lemus Castro, Jorge; Brochado, Leonardo; Armesto, Wilfredo; Camargo Vasquez, Tomas; Martínez Bula, Eduardo; Avendaño Echavez, Lil Geraldine; Hernández-Agudelo, Sandra; Turizo Turizo, Erika; Peña Vargas, William; Riascos, William; Sierra, Angélica; Varón Suarez, Favio; Gómez Giraldo, Luisa; Gonzalez-Torres, Henry; Navarro Quiroz, Elkin; Vásquez Obeso, Esteban; Ángel Depine, Santos; Ospino Herrera, DanielObjetivo: Presentar una serie de casos de COVID-19 con requerimiento de ingreso a Unidad de Cuidados Intensivos. Métodos: La información fue tomada de las historias clínicas, y su evaluación y diagnóstico fue realizado mediante estudios paraclínicos en sangre, orina, PCR e imágenes diagnósticas en 4 pacientes con diferentes comorbilidades y nexo epidemiológico presente para desarrollo de la enfermedad. El caso 1 desarrolló falla orgánica múltiple, incluyendo injuria renal aguda con una estancia en UCI de 4 dias antes de su fallecimiento, mientras los casos 2, 3 y 4 tuvieron una evolución favorable y fueron dados de alta de UCI. Los cuatro casos fueron manejados con cloroquina 300 mg via oral cada 12 horas y azitromicina 1 gr via oral cada 24 horas durante 5 dias sin complicaciones ni toxicidad asociada. Conclusiones: Se requieren estudios multicéntricos rápidos que orienten científicamente hacia un mejor abordaje diagnóstico y manejo, en el contexto de una enfermedad con un comportamiento clínico-epidemiologico que debe estudiarse en profundidad y que probablemente cobrará muchas vidas, ademas, debido a la ausencia de pruebas diagnósticas rápidas, la utilización de una clasificación basada en la severidad de lesiones radiológicas llamada CO-RADS (Covid-19 Imaging Reporting and Data System), podría ser de gran importancia para instalar de manera temprana los tratamientos farmacológicos disponibles y la asistencia respiratoria mecánica precoz.