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Dialysis prescription in acute kidney injury: when and how much?
Acute kidney injury (AKI) constitutes a serious public health problem because of its very high cost and mortality rate, with an increasing incidence, phenomenon which is explained by the increasingly number of older patients suffering from several comorbidities admitted in the intensive care units. Despite the new AKI definition and classification, the use of novel AKI biomarkers and modern technologies, as an attempt to achieve an early AKI detection and treatment, and consequently to better clinical outcomes, AKI mortality particularly in ICU ...
Nucleocapsid protein precursors NCp9 and NCp15 suppress ATP-mediated rescue of AZT-terminated primers by HIV-1 reverse transcriptase
(American Society for Microbiology, 2020)
In HIV-1, development of resistance to AZT (3′-azido-3′-deoxythymidine) is mediated by the acquisition of thymidine analogue resistance mutations (TAMs) (i.e. M41L, D67N, K70R, L210W, T215F/Y and K219E/Q) in the viral reverse transcriptase (RT). Clinically relevant combinations of TAMs such as M41L/T215Y or D67N/K70R/T215F/K219Q enhance the ATP-mediated excision of AZT monophosphate (AZTMP) from the 3′ end of the primer, allowing DNA synthesis to continue. Additionally, during HIV-1 maturation, the Gag polyprotein is cleaved to release a mature ...