Mostrar el registro sencillo del ítem

dc.contributor.authorRojas, Edwardspa
dc.contributor.authorBermúdez, Valmorespa
dc.contributor.authorMotlaghzadeh, Yasamaneng
dc.contributor.authorMathew, Justineng
dc.contributor.authorFidilio, Enzamariaspa
dc.contributor.authorFaria, Judithspa
dc.contributor.authorRojas, Joselynspa
dc.contributor.authorCabrera de Bravo, Mayelaspa
dc.contributor.authorContreras, Juliospa
dc.contributor.authorMantilla, Linda Pamelaspa
dc.contributor.authorAngarita, Lisséspa
dc.contributor.authorSepúlveda, Paola Amarspa
dc.contributor.authorKuzmar, Isaacspa
dc.date.accessioned2019-07-18T23:41:43Z*
dc.date.available2019-07-18T23:41:43Z*
dc.date.issued2018
dc.identifier.issn21613311
dc.identifier.urihttps://hdl.handle.net/20.500.12442/3585
dc.description.abstractPurpose of Review. Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease. Recent Findings. Despite stevia’s minimal systemic absorption, studies have been promising regarding its potential benefits against inflammation, carcinogenesis, atherosclerosis glucose control, and hypertension. On the other hand, the growing popularity of artificial sweeteners does not correlate with improved trends in obesity. An increased intake of artificial non-caloric sweeteners may not be associated with decreased intake of traditional sugar-sweetened beverages and foods. The effects of Stevia on weight change have been linked to bacteria in the intestinal microbiome, mainly by affecting Clostridium and Bacteroides sp. populations. A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro. Summary. Consumption of Stevia has demonstrated to be generally safe in most reports. Further clinical studies are warranted to determine if regular consumption brings sustained benefits for human health.spa
dc.language.isoengeng
dc.publisherSpringerspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceCurrent Nutrition Reportseng
dc.sourceSeptember 2018, Volume 7, Issue 3eng
dc.source.urihttps://doi.org/10.1007/s13668-018-0228-zeng
dc.subjectStevia rebaudiana Bertonieng
dc.subjectObesityeng
dc.subjectType 2 diabeteseng
dc.subjectHypertensioneng
dc.titleStevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndromeeng
dc.typearticleeng
dcterms.referencesOgden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States, 2011–2014. NCHS data brief 2015. Num 219. Hyattsville: National Center for Health Statistics.eng
dcterms.referencesObesity and overweight. World health organization fact sheet. 2017. Available at: https://www.who.int/mediacentre/factsheets/fs311/en/ (Accessed 12/31/2017).eng
dcterms.referencesGarvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, et al. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract. 2016;22(Supp3):1–205.eng
dcterms.referencesGoyal SK, Samsher, Goyal RK. Stevia (Stevia rebaudiana) a bio-sweetener: a review. Int J Food Sci Nutr. 2010;61(1):1–10. https://doi.org/10.3109/09637480903193049.eng
dcterms.referencesAtteh J, Onagbesan O, Tona K, Decuypere E, Geuns J, Buyse J. Evaluation of supplementary Stevia (Stevia rebaudiana Bertoni) leaves and stevioside in broiler diets: effects on feed intake, nutrient metabolism, blood parameters and growth performance. J Anim Physiol Anim Nutr. 2008;92(6):640–9.eng
dcterms.referencesKroyer G. Stevioside and Stevia-sweetener in food: application, stability and interaction with food ingredients. J. Verbr. Lebensm. 2010;5:225–9. https://doi.org/10.1007/s00003-010-0557-3.eng
dcterms.referencesSeema T. Stevia rebaudiana: a medicinal and nutraceutical plant and sweet gold for diabetic patients. Int. J. of Pharm. Life Sci. 2010;1(8):451–7.eng
dcterms.referencesChattopadhyay S, Raychaudhuri U, Chakraborty R. Artificial sweeteners—a review. J Food Sci Technol. 2014;51(4):611–21. https://doi.org/10.1007/s13197-011-0571-1.eng
dcterms.referencesInternational Stevia Council. Available online at: https://www.internationalsteviacouncil.org/fileadmin/media/About_Stevia/stevia_6pp__1_.pdf. Accessed 01/02/2018.eng
dcterms.referencesLe Bertoni M. Kaà He-é Sa nature et ses proprietes. Anales Científicos Paraguayos. 1905;5:1–14.eng
dcterms.referencesKinghorn AD. Stevia: the genus Stevia, vol. 224. Boca Raton: CRC Press; 2003.eng
dcterms.referencesChatsudthipong V, Muanprasat C. Stevioside and related compounds: therapeutic benefits beyond sweetness. Pharmacol Ther. 2009;121:41–54.eng
dcterms.referencesAminha S, Soumya AN, Raju VG, Goud BM, Irfath M, Quadri SAP. Isolation and extraction of artificial sweetener (Stevia). World J Pharm Res. 2014;3:481–6.eng
dcterms.referencesKinghorn AD, Soejarto DD. Current status of stevioside as a sweetening agent for human use. Progress in medicinal and Economic Plan research, vol. 1. London: Academic Press; 1985. p. 1–51.eng
dcterms.referencesCrammer B, Ikan R. Progress in the chemistry and properties of the rebaudiosides. In: Grenby, editor. Developments in Sweeteners 1987. London: Elsevier Applied Science; 1987. p. 45–64.eng
dcterms.referencesPhillips KC. Stevia: steps in developing a new sweetener. In: Grenby TH, editor. Developments in sweeteners. Vol 3. London: Elsevier Applied Science; 1987. p. 1–43.eng
dcterms.referencesBridel M, Lavieille R. Le principe a saveur sucree du Kaa-he-e (Stevia Rebaudiana) Bertoni. Bull Soc Chim Biol. 1931;13:636–55.eng
dcterms.referencesKhoda H, Kaisai R, Yamasaki K, Tanaka O. New sweet diterpene glucose from Stevia rebaudiana. Phytochemistry. 1976;15:981–3.eng
dcterms.referencesKinghorn D, Soejarto DD, Nanyakkare NPD, Compadre CM, Makapugay HC, Hovanec-Brown JM, et al. A phytochemical screening procedure for sweet ent-Kaurene glycosides in the genus Stevia. Nat Prod. 1984;47:439–44.eng
dcterms.referencesSavita S, Sheela K, Sunanda S, Shankar A, Ramakrishna P. Stevia rebaudiana—a functional component for food industry. J Hum Ecol. 2004;15:261–4.eng
dcterms.referencesMauri P, Catalano G, Gardana C, Pietta P. Analysis of Stevia glyosides by capillary electrophoresis. Electrophoresis. 1997;17:376–1.eng
dcterms.referencesMadan S, Ahmad S, Singh GN, Kohli K, Kumar Y, Singh R, et al. Stevia rebaudiana (Bert.) Bertoni—a review. Indian J Nat Prod Resour. 2010;1(3):267–86.eng
dcterms.referencesGupta E, Purwar S, Sundaram S, Rai GK. Nutritional and therapeutic values of Stevia rebaudiana: a review. J Med Plants Res. 2013;7(46):3343–53.eng
dcterms.referencesHutapea AM, Toskulkao C, Buddhasukh D, Wilairat P, Glinsukon T. Digestion of stevioside, a natural sweetener, by various digestive enzymes. J Clin Biochem Nutr. 1997;23:177–86.eng
dcterms.referencesKoyama E, Kitazawa K, Ohori Y, Izawa O, Kakegawa K, Fujino A, et al. In vitro metabolism of the glycosidic sweeteners, Stevia mixture and enzymatically modified Stevia in human intestinal microflora. Food Chem Toxicol. 2003;41:359–74.eng
dcterms.referencesSimonetti P, Gardana C, Bramati L, Pietta PG. Bioavailability of Stevioside from Stevia rebaudiana in human volunteers: preliminary report. Proceedings of the first symposium on the safety of stevioside, April 16, 2004. Heverlee-Leuven, Belgium: Euprint Editions, pp. 51–62.eng
dcterms.referencesMagnuson BA, Carakostas MC, Moore NH, Poulos SP, Renwick AG. Biological fate of low-calorie sweeteners. Nutr Rev. 2016;74(11):670–89. https://doi.org/10.1093/nutrit/nuw032.eng
dcterms.referencesGeuns JMC, Buyse J, Vankeirsbilck A, Temme EHM. Metabolism of stevioside by healthy subjects. Exp Biol Med. 2007;232:164–73.eng
dcterms.referencesNikiforov AI, Rihner MO, Eapen AK, Thomas JA. Metabolism and toxicity studies supporting the safety of rebaudioside D. Int J Toxicol. 2013;32(4):261–73. https://doi.org/10.1177/1091581813492828.eng
dcterms.referencesTucker AO, Debaggio T. The encyclopedia of Herbs. A comprehensive review of flavor and fragrance. Portland: Timber Press; 2009. p. 467–71.eng
dcterms.referencesAmerican Diabetes Association Standards of Medical Care in Diabetes. Lifestyle Management. Diabetes Care. 2017;40(Suppl. 1):S33–43. https://doi.org/10.2337/dc17-S007.eng
dcterms.referencesNorazlanshah H, Azizah M, Muhammad I, Mashita M, Khairil A, Norazmir N, et al. Effect of acute Stevia consumption on blood glucose response in healthy Malay young adults. Sains Malaysiana. 2014;43(5):649–54.eng
dcterms.referencesMukhtar M, Tiong CS, Bukhari SI, Abdullah AH, Ming LC. Safety and efficacy of health supplement (Stevia rebaudiana). Arch Pharma Pract. 2016;7(Suppl S1):16–21.eng
dcterms.referencesSuanarunsawat T, Klongpanichapak S, Rungseesantivanon S, Chaiyabutr N. Glycemic effect of stevioside and Stevia rebaudiana in streptozotocin-induced diabetic rats. East J Med. 2009;9:51–6.eng
dcterms.referencesNaveen S, Mahadev N, Farhath K, Vijay KK. Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. J Diabetes Complicat. 2013;27:103–13.eng
dcterms.referencesAssaei R, Mokarram P, Dastghaib S, Darbandi S, Darbandi M, Zal F, et al. Hypoglycemic effect of aquatic extract of Stevia in pancreas of diabetic rats: PPARγ -dependent regulation or antioxidant potential. Avicenna J Med Biotech. 2016;8(2):65–74.eng
dcterms.referencesPhilippaert K, Pironet A, Mesuere M, Sones W, Vermeiren L, Kerselaers S, et al. Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. Nat Commun. 2017;8:14733. https://doi.org/10.1038/ncomms14733.eng
dcterms.referencesGregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism. 2004;53(1):73–6. https://doi.org/10.1016/j.metabol.2003.07.013.eng
dcterms.referencesRuiz-Ruiz JC, Moguel-Ordoñez YB, Matus-Basto AJ, Segura-Campos MR. Antidiabetic and antioxidant activity of Stevia rebaudiana extracts (Var. Morita) and their incorporation into a potential functional bread. J Food Sci Technol. 2015;52(12):7894–903. https://doi.org/10.1007/s13197-015-1883-3.eng
dcterms.referencesSylvetsky AC, Welsh JA, Brown RJ, Vos MB. Low-calorie sweetener consumption is increasing in the United States. Am J Clin Nutr. 2012;96(3):640–6. https://doi.org/10.3945/ajcn.112.034751.eng
dcterms.referencesFowler SP, Williams K, Resendez RG, Hunt KJ, Hazuda HP, Stern MP. Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain. Obesity (Silver Spring). 2008;16(8):1894–900. https://doi.org/10.1038/oby.2008.284.eng
dcterms.referencesColditz GA, Willett WC, Stampfer MJ, London SJ, Segal MR, Speizer FE. Patterns of weight change and their relation to diet in a cohort of healthy women. Am J Clin Nutr. 1990;51(6):1100–5.eng
dcterms.referencesde Koning L, Malik VS, Rimm EB, Willett WC, Hu FB. Sugar sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men. Am J Clin Nutr. 2011;93(6):1321. https://doi.org/10.3945/ajcn.110.007922.eng
dcterms.referencesMattes RD, Popkin BM. Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr. 2009;89(1):1–14. https://doi.org/10.3945/ajcn.2008.26792.eng
dcterms.referencesHruby A, Hu FB. The epidemiology of obesity: a big picture. Pharmacoeconomics. 2015;33(7):673–89. https://doi.org/10.1007/s40273-014-0243-x.eng
dcterms.referencesO’Connor L, Imamura F, Lentjes MA, Khaw KT, Wareham NJ, Forouhi NG. Prospective associations and population impact of sweet beverage intake and type 2 diabetes, and effects of substitutions with alternative beverages. Diabetologia. 2015;58(7):1474–83. https://doi.org/10.1007/s00125-015-3572-1.eng
dcterms.referencesDuffey KJ, Steffen LM, Van Horn L, Jacobs DR Jr, Popkin BM. Dietary patterns matter: diet beverages and cardiometabolic risks in the longitudinal Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr. 2012;95(4):909–15. https://doi.org/10.3945/ajcn.111.026682.eng
dcterms.referencesGardener H, Rundek T, Markert M, Wright CB, Elkind MS, Sacco RL. Diet soft drink consumption is associated with an increased risk of vascular events in the Northern Manhattan study. J Gen Intern Med. 2012;27(9):1120–6. https://doi.org/10.1007/s11606-011-1968-2.eng
dcterms.referencesBernstein AM, de Koning L, Flint AJ, Rexrode KM, Willett WC. Soda consumption and the risk of stroke in men and women. Am J Clin Nutr. 2012;95(5):1190–9. https://doi.org/10.3945/ajcn.111.030205.eng
dcterms.referencesChia CW, Shardell M, Tanaka T, Liu DD, Gravenstein KS, Simonsick EM, et al. Chronic low-calorie sweetener use and risk of abdominal obesity among older adults: a cohort study. PLoS One. 2016;11(11):e0167241. https://doi.org/10.1371/journal.pone.0167241.eng
dcterms.referencesFagherazzi G, et al. Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the etude Epidemiologique aupres des femmes de la Mutuelle Generale de l’Education Nationale-European prospective investigation into Cancer and nutrition cohort. Am J Clin Nutr. 2013;97:517–23.eng
dcterms.referencesGardener H, et al. Diet soft drink consumption is associated with an increased risk of vascular events in the Northern Manhattan study. J Gen Intern Med. 2012;27:1120–6.eng
dcterms.referencesCohen L, et al. Association of sweetened beverage intake with incident hypertension. J Gen Intern Med. 2012;27:1127–34.eng
dcterms.referencesDuffey KJ, et al. Dietary patterns matter: diet beverages and cardiometabolic risks in the longitudinal Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr. 2012;95:909–15.eng
dcterms.referencesSwithers SE. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab. 2013;24(9):431–41. https://doi.org/10.1016/j.tem.2013.05.005.eng
dcterms.referencesAnton SD, Martin CK, Hongmei H, Coulon S, Cefalu WT, Geiselman P, et al. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite. 2010;55(1):37–43. https://doi.org/10.1016/j.appet.2010.03.009.eng
dcterms.referencesRuanpeng D, Thongprayoon C, Cheungpasitporn W, Harindhanavudhi T. Sugar and artificially-sweetened beverages linked to obesity: a systematic review and meta-analysis. QJM. 2017;110(8):513–20. https://doi.org/10.1093/qjmed/hcx068.eng
dcterms.referencesDurán Agüero S, Vásquez Leiva A, Morales Illanes G, Schifferli Castro I, Sanhueza Espinoza C, Encina Vega C, et al. Consumo de stevia en estudiantes universitarios chilenos y su asociación con el estado nutricional. Nutr Hosp. 2015;32:362–6. https://doi.org/10.3305/nh.2015.32.1.8961.eng
dcterms.referencesAzad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys L, Copstein L, et al. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. CMAJ. 2017;189:E929–39. https://doi.org/10.1503/cmaj.161390.eng
dcterms.referencesAshwell M. Stevia, nature’s zero-calorie sustainable sweetener a new player in the fight against obesity. Nutr Today. 2015;50(3):129–34. https://doi.org/10.1097/NT.0000000000000099.eng
dcterms.referencesPearlman M, Obert J, Casey L. The association between artificial sweeteners and obesity. Curr Gastroenterol Rep. 2017;19:64. https://doi.org/10.1007/s11894-017-0602-9.eng
dcterms.referencesQin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):55–60. https://doi.org/10.1038/nature11450.eng
dcterms.referencesKarlsson FH, Tremaroli V, Nookaew I, Bergstrom G, Behre CJ, Fagerberg B, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013;498(7452):99–103. https://doi.org/10.1038/nature12198.eng
dcterms.referencesGardana C, Simonetti P, Canzi E, et al. Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. J Agric Food Chem. 2003;51:6618–22.eng
dcterms.referencesVijay-Kumar M, Aitken JD, Carvalho FA, et al. Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science. 2010;328:228–31.eng
dcterms.referencesBackhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci. 2004;101:15718–23.eng
dcterms.referencesSuez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014;514(7521):181–6. https://doi.org/10.1038/nature13793.eng
dcterms.referencesRenwick AG, Tarka SM. Microbial hydrolysis of steviol glycosides. Food Chem Toxicol. 2008;46(suppl 7):S70–4.eng
dcterms.referencesSheiham A, James WPT. A reappraisal of the quantitative relationship between sugar intake and dental caries: the need for new criteria for developing goals for sugar intake. BMC Public Health. 2014;14:863.eng
dcterms.referencesGiacaman RA, Campos P, Muñoz-Sandoval C, Castro RJ. Cariogenic potential of commercial sweeteners in an experimental biofilm caries model on enamel. Arch Oral Biol. 2013;58:1116–22.eng
dcterms.referencesGamboa F, Chaves M. Antimicrobial potential of extracts from Steoooovia rebaudiana leaves against bacteria of importance in dental caries. Acta Odontol Latinoam. 2012;25:171–5.eng
dcterms.referencesDe Slavutzky SMB. Stevia and sucrose effect on plaque formation. J Verbr Lebensm. 2010;5:213–6.eng
dcterms.referencesBrambilla E, Cagetti MG, Ionescu A, Campus G, Lingström P. An in vitro and in vivo comparison of the effect of Stevia rebaudiana extracts on different caries-related variables: a randomized controlled trial pilot study. Caries Res. 2014;48:19–23.eng
dcterms.referencesFerrazzano GF.; Cantile, T.; Alcidi, B.; Coda, M.; Ingenito, A.; Zarrelli, A, ; Di Fabio, G.; Pollio, A. Is Stevia rebaudiana Bertoni a non cariogenic sweetener? A Review Molecules 2016, 21, 38; doi: https://doi.org/10.3390/molecules21010038.eng
dcterms.referencesWang T, et al. Stevioside plays an anti-inflammatory role by regulating the NF-κB and MAPK pathways in S. aureus-infected mouse mammary glands. Inflammation. 2014;37(5):1837–46.eng
dcterms.referencesBunprajun T, et al. Stevioside enhances satellite cell activation by inhibiting of NF-κB signaling pathway in regenerating muscle after cardiotoxin-induced injury. J Agric Food Chem. 2012;60(11):2844–51.eng
dcterms.referencesKim S-Y, et al. Anti-inflammatory effect of Stevia Rebaudiana as a results of NF-kB and MAPK inhibition. J Korean Med Opthalmol Otolaryngol Dermatol. 2013;26(3):54–64.eng
dcterms.referencesBoonkaewwan C, Toskulkao C, Vongsakul M. Anti-inflammatory and immunomodulatory activities of stevioside and its metabolite steviol on THP-1 cells. J Agric Food Chem. 2006;54(3):785–9.eng
dcterms.referencesBoonkaewwan C, Burodom A. Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells. J Sci Food Agric. 2013;93(15):3820–5.eng
dcterms.referencesStevenson TH. The effects of stevia on cytokine production in human THP-1 monocytes. Cardiff Metropolitan University Repository 2017. Availble at: https://hdl.handle.net/10369/8962. Accessed 01/05/2018.eng
dcterms.referencesElzinga SE, et al. Metabolic and inflammatory responses to the common sweetener stevioside and a glycemic challenge in horses with equine metabolic syndrome. Domest Anim Endocrinol. 2017;60(Supplement C):1–8.eng
dcterms.referencesSehar I, Kaul A, Bani S, Chandra H, Kumar AS. Immune up regulatory response of a non-caloric natural sweetener, stevioside. Chem Biol Interact. 2008;173:115–21.eng
dcterms.referencesGeeraert B, et al. Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice. Int J Obes. 2009;34:569eng
dcterms.referencesKannel WB, McGee DL. Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study. Diabetes Care. 1979;2(2):120–6.eng
dcterms.referencesFujishima M, et al. Diabetes and cardiovascular disease in a prospective population survey in Japan: the Hisayama study. Diabetes. 1996;45(Supplement 3):S14–6.eng
dcterms.referencesUlbricht C, Isaac R, Milkin T, Poole EA, Rusie E, Serrano JMG, et al. An evidence-based systematic review of Stevia by the natural standard research collaboration. Cardiovasc Hematol Agents Med Chem. 2010;8:113–27.eng
dcterms.referencesRoberts A, Munro I. Stevioside and related compounds: therapeutic benefits beyond sweetness. Pharmacol Ther. 2009;122eng
dcterms.referencesMelis M, Sainati A. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol. 1991;33:257–62.eng
dcterms.referencesMelis M. Stevioside effect on renal function of normal and hypertensive rats. J Ethnopharmacol. 1992;36:213–7.eng
dcterms.referencesMelis M. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol. 1995;47:129–34.eng
dcterms.referencesMelis M. Effects of Steviol on renal function and mean arterial pressure in rats. Phytomedicine. 1997;3:349–52.eng
dcterms.referencesMelis M. Effect of crude extract of Stevia rebaudiana on renal water and electrolytes excretion. Phytomedicine. 1999;6:247–50.eng
dcterms.referencesLiu J-C, Kao P-K, Chan P, Hsu Y-H, Hou C-C, Lien G-S, et al. Mechanism of the antihypertensive effect of stevioside in anesthetized dogs. Pharmacology. 2002;67:14–20.eng
dcterms.referencesLee C-N, Wong K-L, Liu J-C, Chen Y-J, Cheng J-T, Chan P. Inhibitory effect of Stevioside on calcium influx to produce antihypertension. Planta Med. 2001;67:796–9.eng
dcterms.referencesJeppesen P, Gregersen S, Rolfsen S, Jepsen M, Colombo M, Agger A, et al. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism. 2003;52:372–8.eng
dcterms.referencesDe-Yi X, Hong C, Yuan-Yuan L. The antihypertensive effects by stevioside in the conscious nomal and hypertensive rats. Eur J Pharmacol. 1822;1990:183.eng
dcterms.referencesChan P, Tomlinson B, Chen Y, Liu J, Hsieh M, Cheng J. A doubleblind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol. 2000;50:215–20.eng
dcterms.referencesHsieh M-H, Chan P, Sue Y-M, Liu J-C, Liang TH, Huang T-Y, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther. 2003;25:2797–808.eng
dcterms.referencesSavita S, Sheela K, Sunanda S, Shankar A, Ramakrishna P, Sakey S. Health implications of Stevia rebaudiana. J Hum Ecol. 2004;15:191–4.eng
dcterms.referencesBarriocanal LA, Palacios M, Benitez G, Benitez S, Jimenez JT, Jimenez N, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in type 1 and type 2 diabetics. Regul Toxicol Pharmacol. 2008;51:37–41.eng
dcterms.referencesMasuda T, Yamashita D, Maekawa T, Sone Y, Yamaguchi H, Takeda Y, et al. Identification of antioxidative compounds from Stevia (Stevia rebaudiana). Nippon Shokuhin Kagaku Kogaku Kaishi. 2006;53:597–602.eng
dcterms.referencesKonoshima T, Takasaki M. Cancer-chemopreventive effects of natural sweeteners and related compounds. Pure Appl Chem. 2002;74eng
dcterms.referencesNakamura Y, Sakiyama S, Takenaga K. Suppression of syntheses of high molecular weight nonmuscle tropomyosins in macrophages. Cell Motil Cytoskeleton. 1995;31:273–82.eng
dcterms.referencesAkihisa T, Hamasaki Y, Tokuda H, Ukiya M, Kimura Y, Nishino H. Microbial transformation of isosteviol and inhibitory effects on Epstein−Barr virus activation of the transformation products. J Nat Prod. 2004;67:407–10.eng
dcterms.referencesKaushik R, Narayanan P, Vasudevan V, Muthukumaran G, Usha A. Nutrient composition of cultivated stevia leaves and the influence of polyphenols and plant pigments on sensory and antioxidant properties of leaf extracts. J Food Sci Technol. 2010;47:27–33.eng
dcterms.referencesYasukawa K. Inhibitory effect of a combined treatment of glycyrrhizin and caffeine on tumor promotion by 12-O-tetradecanoylphorbol-13- acetate in two-stage carcinogenesis in mouse skin. J. Pharm. Nutr. Sci. 2013:202–5.eng
dcterms.referencesMizushina Y, Akihisa T, Ukiya M, Hamasaki Y, Murakami-Nakai C, Kuriyama I, et al. Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. Life Sci. 2005;77:2127–40.eng
dcterms.referencesSalim EI. Inhibitory effects of 1,3-diaminopropane, an ornithine decarboxylase inhibitor, on rat two-stage urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis. 2000;21:195–203.eng
dcterms.referencesSuttajit M, Vinitketkaumnuen U, Meevatee U, Buddhasukh D. Mutagenicity and human chromosomal effect of stevioside, a sweetener from Stevia rebaudiana Bertoni. Environ Health Perspect. 1993;101:53–6.eng
dcterms.referencesMatsui M, Matsui K, Kawasaki Y, Oda Y, Noguchi T, Kitagawa Y, et al. Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays. Mutagenesis. 1996;11:573–9.eng
dcterms.referencesGlinsukon T, Pimbua J, Panichkul T. Stevioside: a natural sweetener from Stevia rebaudiana Bertoni: toxicological evaluation. Thai J Toxicology. 1988, 4, 1–22.eng
dcterms.referencesPanichkul T, Glinsukon T, Buddhasukh D, Cheuychit P, Pimolsri U. The plasma levels of urea nitrogen, creatinine and uric acid and urine volume in rats and hamsters treated with stevioside. Thai J Toxicology. 1988;4:47–52.eng
dcterms.referencesJones G. “Stevia”. NebGuide: University of Nebraska–Lincoln Institute of Agriculture and Natural Resources. Feb 2014.eng
dcterms.referencesJapan Food Chemical Research Foundation. List of Existing Food Additives [Complied and published by the Ministry of Health and Welfare on April 16, 1996. Tokyo, Japan: Ministry of Health, Labor and Welfare, Japan (MHLW) and Japan Food Chemical Research Foundation (JFCRF). Available at: https://www.ffcr.or.jp/zaidan/FFCRHOME.nsf/pages/list-exst.add [Effective from January 30, 2014, Last update: 04/10/2014].eng
dcterms.referencesBrusick DJ. A critical review of the genetic toxicity of steviol and steviol glycosides. Food Chem Toxicol. 2008;2008(46):S83–91.eng
dcterms.referencesUrban JD, Carakostas MC, Taylor SL. Steviol glycoside safety: are highly purified steviol glycoside sweeteners food allergens? Food Chem Toxicol. 2015;75:71–8.eng
dcterms.referencesJECFA. Steviol glycosides [Prepared at the 73rd JECFA (2010) and published in FAO JECFA Monographs 10 (2010)]. In: Combined Compendium of Food Additive Specifications [Online Edition]. General Specifications for Enzymes Analytical Methods, Volume 4. (FAO JECFA Monographs 10). Rome, Italy: Food and Agriculture Organization of the United Nations (FAO), Joint FAO/WHO Expert Committee on Food Additives (JECFA). Available at: https://www.fao.org/ag/agn/jecfa-additives/specs/monograph10/additive-442-m10.pdf.eng
dcterms.referencesU.S. Food and Drug Administration. Has Stevia been approved by FDA to be used as a sweetener?. Available at https://www.fda.gov/AboutFDA/Transparency/Basics/ucm194320.html.eng
dcterms.referencesEFSA. Scientific opinion on the safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive. (EFSA Panel on Food Additives and Nutrient Sources Added to Food/ANS) (Question no EFSA-Q-2014-00002, adopted on 17 November 2015 by European Food Safety Authority). EFSA J 13(12):4316 [29 pp.]. https://doi.org/10.2903/j.efsa.2015.4316. Available at: https://www.efsa.europa.eu/en/efsajournal/pub/4316.eng
dcterms.referencesMFDS. Enzymatically modified stevia glucosyl stevia. In: Korea Food Additives Code. (All designated chemicals and some natural additives are currently regulated by Food Additives Code. It includes specifications, standards and general test methods for each additives). Korea: Ministry of Food and Drug Safety (MFDS). Available at: https://fa.kfda.go.kr/standard/egongjeon_standard_view.jsp?SerialNo=184&GoCa=2 [Latest English version edition published Feb. 24, 2015].eng
dcterms.referencesHealth Canada. Information and Consultation Document on Health Canada's Proposal to Allow the Use of the Food Additive Steviol Glycosides as a Table-Top Sweetener and as a Sweetener in Certain Food Categories. Ottawa (ON): Health Canada, Bureau of Chemical Safety, Food Directorate. Available at: https://www.hc-sc.gc.ca/fn-n/consult/steviol/document-consultation-eng.php#a12 [Date Modified: 2012–11-30].eng
dcterms.referencesGovernment of Malaysia. Part VIII. Standards and particular labelling requirements for food. Sweetening substance. 118B. Enzymatically modified stevia. In: Laws of Malaysia: P.U.(A) 437 of 1985 Food Act 1983: Food Regulations 1985. Putrajaya, Malaysia: Government of Malaysia. Available at: https://www.asianfoodreg.com/dynamicAssets/regulationDoc/1412157254_Malaysian-Food-Regulations-19852014.pdf.eng
dcterms.referencesFSANZ (2008). Final Assessment Report: Application A540 Steviol Glycosides as Intense Sweeteners. Canberra, Australia: Food Standards Australia New Zealand (FSANZ). Available at: https://www.foodstandards.gov.au/code/applications/documents/FAR_A540_Steviol_gl ycosides.pdf.eng
dcterms.referencesFSANZ (2015). A1108–Rebaudioside M as a Steviol Glycoside Intense Sweetener. (Application to Change Food Standards Code). Canberra, Australia / Wellington, NZ: Foods Standards Australia New Zealand (FSANZ). Available at: https://www.foodstandards.gov.au/code/applications/Pages/A1108-RebaudiosideM-SteviolGlycosideIntenseSweetener.aspx.eng
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

  • Artículos
    Artículos científicos evaluados por pares

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional