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Mostrando ítems 11-16 de 16
Microbiota and Diabetes Mellitus: Role of Lipid Mediators
(MDPI, 2020)
Diabetes Mellitus (DM) is an inflammatory clinical entity with different mechanisms involved in its physiopathology. Among these, the dysfunction of the gut microbiota stands out. Currently, it is understood that lipid products derived from the gut microbiota are capable of interacting with cells from the immune system and have an immunomodulatory effect. In the presence of dysbiosis, the concentration of lipopolysaccharides (LPS) increases, favoring damage to the intestinal barrier. Furthermore, a pro-inflammatory environment prevails, and a ...
Prevalence of physical inactivity and associated cardiometabolic risk factors: A cross-sectional study
(Saber UCV, Universidad Central de Venezuela, 2020)
Physical inactivity represents a public health problem associated with non-communicable diseases. This study aimed to determine both general and domain-specific prevalence of physical inactivity as well as its association with cardiometabolic factors. Methods: A cross-sectional study was performed, including 2 230 adult individuals from both sexes from Maracaibo city.
Metabolic Syndrome: Is It Time to Add the Central Nervous System?
(MDPI, 2021-06)
Metabolic syndrome (MS) is a set of cardio-metabolic risk factors that includes central obesity, hyperglycemia, hypertension, and dyslipidemias. The syndrome affects 25% of adults worldwide. The definition of MS has evolved over the last 80 years, with various classification systems and criteria, whose limitations and benefits are currently the subject of some controversy. Likewise, hypotheses regarding the etiology of MS add more confusion from clinical and epidemiological points of view. The leading suggestion for the pathophysiology of MS is ...
Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela
(Hindawi, 2021)
Background. Visceral adiposity is related to insulin resistance (IR), a metabolic state considered as a risk factor for other cardiometabolic diseases. In that matter, mathematical indexes such as the visceral adiposity index (VAI) and the lipid accumulation product (LAP) could indirectly assess IR based on visceral adiposity. Objective. To evaluate the association and diagnostic accuracy of VAI and LAP to diagnose IR in the adult population of Maracaibo city. Methods. This is a cross-sectional descriptive study with multistage sampling. Receiver ...
Sistema computacional para la detección de glioblastomas en resonancia magnética usando aprendizaje no supervisado
(Saber UCV, Universidad Central de Venezuela, 2020)
La imagenología por resonancia magnética convencional o avanzada es fundamental en la valoración de diversos tipos de tumores, incluyendo los glioblastomas. Ante la gran heterogeneidad e invasividad de estos, su manejo en la actualidad constituye un desafío complejo para los especialistas clínicos y neurocirujanos, así como para los desarrolladores de sistemas computacionales orientados al apoyo diagnóstico y de seguimiento. El presente sistema se utiliza para localizar y visualizar los glioblastomas en un conjunto de 11 bases de datos de uso ...
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis
(MDPI, 2022)
Cardiovascular disease (CVD) is a global public health issue due to its high morbidity, mortality, and economic impact. The implementation of innovative therapeutic alternatives for CVD is urgently required. Specialized proresolving lipid mediators (SPMs) are bioactive compounds derived from ω-3 and ω-6 fatty acids, integrated into four families: Lipoxins, Resolvins, Protectins, and Maresins. SPMs have generated interest in recent years due to their ability to promote the resolution of inflammation associated with the pathogeneses of numerous ...